Panama is one of the smaller licensing jurisdictions for online gambling, but there are a few recognizable brands that call it home. It's an attractive place to launch an operation due to minimal governmental interference and a gambling-friendly banking industry. Additionally, the country's infrastructure is modern and well-maintained in urban areas.

Panama became a licensing jurisdiction in 2002 with the passage of the Online Gaming Act of 2002. The first license was issued in 2003 and Panama has remained in the business ever since. The Junta de Control de Juegos (Gaming Control Board) is responsible for issuing licenses and monitoring the operations of all licensed gambling sites.

Anyone interested in hosting a gaming company in Panama must submit an application and open the business for inspection for as long as it remains in business. The initial inspection includes a criminal background check, business processes analysis, and testing of the "fairness" of all games of chance.